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In mice and rats, standard two-year carcinogenicity studies with insulin glargine were performed at doses up to 0.455 mg/kg, which was for the rat approximately 65 times the recommended human subcutaneous starting dosage of 0.2 units/kg/day (0.007 mg/kg/day) on a mg/kg basis

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Use of diuretics and outcomes in patients with type 2 diabetes: findings from the EMPA-REG OUTCOME trial

G., Antioxidative Effects of Ascorbic Acid and Astaxanthin on ARPE19 Cells in an Oxidative Stress Model, Antioxidants 9 (2020): 9, 10.3390/antiox9090833

Compared with healthy individuals, patients with sarcopenia have an abnormal gut microbiome profile characterized by the alteration of certain gut microbes correlated with host serotonin metabolism [180]