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In the biggest phase 3 study that looked at orforglipron stacked up against a placebo in patients with diabetes , weight reduction on the largest dose (36mg) was 7.9% over 40 weeks

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Guo Y., Liu X., Li T., Zhao J., Yang Y., Yao Y., Wang L., Yang B., Ren G., Tan Y., et al

Identify patterns like concerns about customer service and claims handling
Novo scientists are still mining the data for insights about the drugs effects

Trials will therefore require structured support slow titration, proactive side-effect management, nutritional and exercise guidance, and caregiver involvement to prevent dilution of efficacy signals
