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However, the substantial budget impact of covering obesity treatments is a major concern, which given the size of the potential target patient population could even exhaust the entire Part D budget under certain scenarios

[1] [2] As of mid-2025, retatrutide has not received approval from the MHRA or EMA and remains under clinical investigation (ClinicalTrials

Effects of liraglutide in hypothalamic arcuate nucleus of obese mice

Although the general opposing behavioral outcomes related to food-motivated behavior for the GLP-1 and ghrelin systems are similar across sexes, the specific underlying mechanisms mediating neural sites of action can diverge