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Clinical Recommendations to Manage Gastrointestinal Adverse Events in Patients Treated with Glp-1 Receptor Agonists: A Multidisciplinary Expert Consensus

Causes * Severe muscle injury or crush injury * Prolonged seizures * Strenuous exercise * Burns * Electrical injuries * Muscle diseases * Certain drugs (e.g., statins) Clinical Features * Dark brown or tea-colored urine * Muscle pain and tenderness * Muscle weakness * Reduced urine output in severe cases Investigations * Urine dipstick positive for blood but few/no RBCs on microscopy * Markedly elevated creatine kinase (CK) * Elevated serum myoglobin Complications * Acute kidney injury * Electrolyte disturbances (especially hyperkalemia) Management * Aggressive IV fluids * Treat underlying cause * Monitor renal function and electrolytes Hemoglobinuria Definition: Presence of free hemoglobin in urine due to intravascular hemolysis

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Signal Transduction and Targeted Therapy , 9 (1)