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In this context, incretin resistance might partially reflect a failure of signal compartmentalization: even when bulk cAMP rises, local RAiN/MERCS nanodomains may be unable to sustain effective signaling (Anton et al., 2022) due to altered receptor trafficking (reduced endosomal residency near contacts) and/or increased PDE-driven cAMP erosion within microcompartments (Austin et al., 2025)

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Enhancing the bodys insulin response : The treatment potentially can promote the bodys natural insulin production, improving its efficiency in managing glucose levels