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Adipocyte, or fat cell, size decreased by over 30%

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85 As a result, a phase 2 study specifically aimed to compare the effects of various doses of DGAT2i alone, and in combination with ACCi, on the resolution of MASH or anti-fibrosis via biopsy is underway (NCT04321031)

A 2024 study published in Nature Scientific Reports surveying over 162,000 patients over an eight-year period reported a significant association of psychiatric symptoms in patients taking GLP-1 RAs, including a 195% risk of depression, 108% risk of anxiety, and 106% increased risk for suicidal behavior

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