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At the highest dose (3/6/9/12 mg escalation scheme), mean HbA1c was reduced by up to 1.6% and weight by nearly 9 kg, which was significantly greater than placebo

Recent research shows that GIP directly regulates the brain's hunger neurons after you eat

U: UpToDate, Fulton DR ed UpToDate [Internet] Waltham, MA: UpToDate
Hippocampal BBB opening has been also demonstrated safely in a proof-of-concept study that also reported an A decrease after opening (Rezai et al., 2020)

GLP-1
