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However, current evidence is still inconclusive to demonstrate a direct negative effect of GLP-1 RAs on LBM loss, largely due to heterogeneity in study designs and the limited number of trials specifically evaluating this endpoint [77]
This may be attributed to patients gradually adapting to the medication during the treatment process or other factors
Restarting after missed doses can therefore recreate part of the escalation burden
Weight stability : Some patients maintain stable weight on lower doses, though systematic evidence for doses below 1.7 mg remains limited
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