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As demonstrated in isolated rat -cells, intact islets and the perfused rat pancreas, Zn 2+ inhibits pyruvate-induced glucagon secretion via opening of K ATP channels and inhibition of -cell electrical activity [593]

This so-called incretin effect is attributed to the insulinotropic action of gut hormones, particularly: Glucose-dependent insulinotropic polypeptide (GIP) Glucagon-like peptide 1 (GLP-1)

Regular blood work and check-ups are especially important for self-managed GLP-1 therapy

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Mechanisms of GLP-1 Receptor Agonist-Induced Weight Loss: A Review of Central and Peripheral Pathways in Appetite and Energy Regulation