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However, due to limitations in data and methodology, clear conclusions could not be drawn, leading to uncertainty about this potential side effect

Commenting on the study, Philip Newland-Jones, consultant pharmacist in diabetes and endocrinology at University Hospital Southampton NHS Foundation Trust, said: I think it is an interesting correlation, but certainly doesnt show causation at this stage with this evidence

Injectable GLP-1 agonists, such as Semaglutide and Liraglutide, continue to dominate the market due to their established efficacy in both diabetes and obesity management

A study on whether and how the activation of GLP-1R affects proliferation and apoptosis of human pancreatic cancer cells has demonstrated that GLP-1RAs might activate cAMP in a GLP-1R-dependent manner, subsequently inhibiting the AKT and ERK1/2 signaling pathways, hence inhibiting the growth of transplanted tumors in vivo , as well as inducing apoptosis and inhibiting the proliferation of a human pancreatic cancer cell line in vitro ( 225)

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