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Both Drugs Are Contraindicated In: Pregnancy (or if pregnancy is planned imminently) Personal or family history of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Known hypersensitivity to the active ingredient or excipients Insurance and Prior Authorization Implications Switching from semaglutide to tirzepatide is a new prescription requiring new prior authorization

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Notably, nearly 50% of the retatrutide phase 2 obesity trial were men, which is higher than in phase 3 clinical trials with tirzepatide (32.5% in SURMOUNT-1 [27]) and semaglutide 2.4 mg (25.9% in STEP-1 [8])

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