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Yao et al., 2019)

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Clinical Benefits of Microdosing: Reduced Side Effects: Lower starting doses minimize nausea, vomiting, and other gastrointestinal symptoms that can lead to treatment discontinuation Individualized Titration: Ability to make small incremental adjustments based on patient response and tolerance Cost Effectiveness: Extended use of each medication vial, making treatment more accessible Improved Adherence: Better tolerability leads to sustained treatment compliance Dosing Protocols for Microdosing: Research supports starting with doses as low as 0.15 mg per week for compounded semaglutide, with gradual titration based on individual response.[5] The flexible dosing allows providers to find the optimal therapeutic dose for each patient while maintaining safety and efficacy