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GLP-1 receptor agonists operate on several levels

The combination treatment of dapagliflozin 5 mg plus metformin HCl extended-release provided statistically significant improvements in HbA1c and FPG compared with either of the monotherapy treatments and statistically significant reduction in body weight compared with metformin HCl extended-release alone (see Table 12)

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However, several unanswered questions remainnamely, whether GLP-1RAs, given their common gastrointestinal side-effects such as nausea, vomiting, and altered bowel habits, are safe and tolerable in patients with IBD

Maternal hypoglycemia during pregnancy in type 1 diabetes: maternal and fetal consequences