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In general, the GLP-1 receptor agonists provide for what we call a dose-response curve

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Who Is a Candidate for This Switch and Safety Considerations Switching from Ozempic to compounded semaglutide is generally appropriate for patients who are stable on their current dose, have no contraindications to GLP-1 receptor agonists, and are motivated by cost or access barriers

Understanding the potential of drugs that target more than one mechanism opens a whole new world of discovery for better weight-loss and diabetes drugs, said senior author Jonathan Campbell, Ph.D., associate professor in the departments of Medicine and Pharmacology and Cancer Biology at Duke University School of Medicine, and member of the Duke Molecular Physiology Institute

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