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The degeneration may be in the form of lesions in the central nervous system, as in multiple system atrophy (MSA), or in loss of autonomic nerves not involving the central nervous system, as in pure autonomic failure (PAF)

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Ubiquinol then scavenges lipid peroxyl radicals, thereby suppressing lipid peroxidation and ferroptosis ( 2.2.3 GCH1-BH4 pathway The guanosine 5-triphosphate (GTP) cyclohydrolase-1 (GCH1)tetrahydrobiopterin (BH4) pathway represents a key GPX4-independent mechanism that inhibits ferroptosis

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