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The SURMOUNT-1 trial demonstrated significant weight loss, with patients losing approximately 15-21% of their body weight at the 15 mg dose over 72 weeks, depending on the statistical method used
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Common side effects include mild gastrointestinal symptoms, which usually subside over time
The decreased production of estrogen in patients receiving GLP-1RA inhibits the collagen synthesis and increases the activity of metalloproteinase-1, leading to matrix collagen and elastin degradation
