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doi: 10.2337/dc13-2855

LMICs Low- and middle-income countries HICs High-income countries NK cells Natural killer cells TNF- Tumor necrosis factor- IL-1 Interleukin-1 IL-6 Interleukin-6 TLR-4 Toll-like receptor-4 LPS Lipopolysaccharide NLRP3 NOD-like receptor protein 3 ROS Reactive Oxygen Species NO Nitric oxide SIM Sepsis-induced Myopathy GLP-1R Glucagon-like peptide-1 receptor GLP-1 Glucagon-like peptide-1 GLP-1RA Glucagon-like peptide-1 receptor agonist PKA Protein kinase A PLC Phospholipase C ERK1/2 Extracellular signal-regulated kinase 1 and 2 DPP-4 Dipeptidyl peptidase-4 IL-1 Interleukin-1 MCP-1 Monocyte Chemoattractant Protein-1 IL-10 Interleukin-10 iNOS Inducible nitric oxide synthase eNOS Endothelial nitric oxide synthase CRP C-reactive protein MDA Malondialdehyde 8-OHdG 8-hydroxy-2deoxyguanosine ICU Intensive Care Unit SOD Superoxide dismutase GPx Glutathione peroxidase Nrf2 Nuclear factor erythroid 1-related factor 2 SAE Sepsis-associated encephalopathy mTOR Mammalian target of rapamycin DPP-4is Dipeptidyl peptidase-4 inhibitors Glossary References 1

2.6% placebo) 63% of participants lost at least 5% 33% lost at least 10% Approximately 14% lost 15% or more What this means practically: For someone weighing 220 pounds: Average result: 18 pounds lost (reaching 202 pounds) Good responder: 22-33 pounds lost (reaching 187-198 pounds) Excellent responder (uncommon): 33+ pounds lost Ozempic/Wegovy (Semaglutide) Weight Loss Results Semaglutides effectiveness was established in the STEP trials: STEP 1 trial (semaglutide 2.4mg): Average weight loss: 14.9% of body weight at 68 weeks (vs