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The mechanism of DPP-4 inhibitors is to increase incretin levels (GLP-1 and GIP), [2] [3] [4] which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels

Instead, the areas under your eyes might appear darker or more hollow, and the nasolabial folds (the lines running from your nose to the corners of your mouth) might become more pronounced

Experience with similar medications suggests that stopping after 3 months would likely result in significant weight regain

The heavier the patient, the more likely they are to accumulate such conditions

Furthermore, pre-synaptic and post-synaptic proteins, synaptophysin and PSD-95, which reflect synaptic disruption [122], were upregulated, neuronal excitability normalized, and intracellular calcium, a key regulator in metabolic dysfunction and progressive neuronal loss [123], was modulated [121]