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Exenatide and dulaglutide showed none

In a meta-analysis of 60 studies involving 60,077 T2D patients, GLP-1RAs marginally reduced the UACR in comparison to placebo and other antidiabetic agents, but resulted in no clinically relevant changes in eGFR ( Renoprotective Mechanisms of GLP-1RAs Experimental studies to elucidate the beneficial effects on DKD have been extensively reported

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Moreover, GLP-1RA limits the inflammation induced by nuclear factor kappa, thereby reducing the expression of proinflammatory mediators like tumor necrosis factor (TNF), C-C motif ligand 2, and IL-6[12]

To investigate the possible mechanism of PanIN progression in humans, Gier et al