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Circulation 96 , 31573163 (1997)

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Understanding variants in GLP1R, GIPR, FTO, and MC4R helps predict not only efficacy but also tolerability, potentially preventing side-effect complications before they start

The study used a cross-over design, meaning that the 30 human volunteers would first receive the same 60 milligram dose of either Nexafed or Sudafed, have blood drawn at various times for pseudoephedrine measurements, and then be subject to a "washout" period during which the drug is completely metabolized and eliminated

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