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Desai DD, Sikora M, Nohria A, Bordone L, Caplan AS, Shapiro J, Lo Sicco KI

LEAP2 is an endogenous antagonist of the ghrelin receptor

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Overall, oral semaglutide compared favorably in terms of the efficacy endpoints examined

Accordingly, pharmacological activation of AMPK in the VMH blunts food intake suppression by i.c.v