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STEP UP: In adults with obesity, along with diet and exercise, Wegovy HD (semaglutide) injection 7.2 mg: Designed to deliver greater weight-loss results than the Wegovy you know 1 Mean change in body weight (%) from week 0 to week 72 1 Co-primary end point 1 : Percentage of patients achieving 5% weight loss at 72 weeks: 88.7% of patients with Wegovy vs 38.3% with placebo HD Treatment regimen estimand: This estimand is based on the intention-to-treat principle and was used as the primary analysis method *Co-primary end point: % change in body weight for Wegovy HD vs placebo

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Brain fog, difficulty concentrating, and memory issues commonly accompany both obesity and depression

Adding another set (e.g., doing 3 sets instead of 2)

Some users have tried intermittent dosing patterns (every 2 weeks instead of weekly, or 6 weeks on followed by 2 weeks off)