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In rodents, human enteroendocrine cells, and in perfused porcine ileum, cholinergic agonists, which bind to receptors in both the enteric and parasympathetic nervous system (PNS), stimulate GLP-1 secretion (4, 14, 84, 192)

Rather than stopping tirzepatide entirely, many people find a maintenance dose that keeps appetite controlled and weight stable without needing continued dose increases

The injection is once per week

Patients with Class I and Class II disease under age 45 are given 30 mCi as an out-patient treatment

The procedure can be performed in-office, and most patients will not require any post-treatment downtime