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For Men, GLP-1s May Help Increase Low Testostone Levels For men, the reproductive effects appear to be mostly indirect

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Method A literature search was performed in PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar during March 2025September 2025, using combinations of the following terms: GLP-1 receptor, GLP-1R agonist, GLP-1 signalling, semaglutide, liraglutide, exenatide, dulaglutide, salivary glands, xerostomia, hyposalivation, oral adverse effects, biased agonism, -arrestin, cAMP, GPCR signaling, albumin binding, pharmacovigilance

Lrke Smidt Gasbjerg, University of Copenhagen, Denmark Updates Copyright 2022 Gallwitz

The graphical abstract of the manuscript has been presented in Figure 2