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Tirzepatide is the first in this class to receive FDA approval, and it targets both the GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

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Future research should prioritize long-term randomized placebo-controlled trials with larger sample sizes to provide stronger evidence on the long-term efficacy and safety of semaglutide for obesity treatment in PWS as well as explore the potential synergistic effects of GLP-1 RA treatment combined with other therapeutic interventions

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