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The analysis showed that metabolic surgery significantly reduced major adverse cardiovascular events over 3.9 years of follow-up, with a hazard ratio of 0.61

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Retatrutide and orforglipron are furthest along in testing, while survodutide may take longer
Nausea is the most commonly reported side effect, followed by constipation, stomach pain, diarrhea, fatigue, and vomiting

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