glp 1 agonist review Frontiers GLP-1 Receptor Agonists | New

There have been reports of gallbladder disease, including cholelithiasis and cholecystitis, possibly related to rapid weight loss

Endothelial dysfunction induced by triglycerides is not restored by exenatide in rat conduit arteries ex vivo

J Appl Physiol

Over 250 patients underwent metabolomics and lipidomic investigations, which revealed that unlike the baseline and placebo, tirzepatide, taken over 26 weeks, significantly impacted a group of lipids and metabolites like 3-hydroxybutyrate reduced branched-chain ketoacids (BCKA), branched-chain amino acids (BCAA), and direct catabolic products linked with obesity and insulin resistance

These effects translate experimentally to altered caloric intake and post-prandial glucose kinetics in rodent and non-human primate models