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As PA has a dose-response relationship, vigorous rather than moderate exercise, such as running, carries the full benefit, including for steatohepatitis and fibrosis
These are more likely to occur within the first weeks of initiation of therapy and with dose escalation
The metanalysis includes 5,323 patients (56-61 years) with T2D inadequately controlled (HbA 1c 7-10.5%), baseline BMI 23-45 kg/m 2 , mean diabetes duration of 9-12 years, and randomized to receive a GLP-1RA or GIP/GLP-1RA versus placebo in add on to basal insulin for at least 24 weeks (24-40 weeks)
Keeping a food diary can help you identify these intolerances
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