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Keywords: incretin therapy, immunogenicity, type 2 diabetes, clinical trial Tirzepatide (TZP) is a once-weekly, glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP-1) receptor agonist (RA) that was recently approved in the United States for the treatment of people with type 2 diabetes and is in development for chronic weight management and nonalcoholic steatohepatitis indications (1)

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