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Important safety considerations include contraindications in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

In the fall, Zepbound, was approved by the agency for weight loss specifically, as opposed to for type 2 diabetes
It is not recommended that an oral equivalent of a weekly subcutaneous dose 1 mg be used instead Comments: The doses of 0.25mg subcutaneously every week and 3mg orally once daily are for the initiation of treatment and not for glycemic management

Active pancreatitis or a history of recurrent pancreatitis is also a contraindication
