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The active ingredient, semaglutide , is a GLP-1 (glucagon-like peptide-1) receptor agonist

We performed metarregression to evaluate if there was a trend towards higher incidence of pancreatic cancer in studies with longer duration, however no association between duration and the outcome was observed

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Meanwhile, large-scale prospective cohort studies from 2024 to 2025, including a multisite analysis of 98,147 GLP-1RA users across six countries, show no evidence of increased thyroid cancer risk [188]

Furthermore, the continuing education of underwriters to ensure accurate interpretation of disclosures and evidence, including risk markers and polypharmacy, is essential