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Simpson discusses his shame, decision to take a GLP-1 and the side effects he's encountered

Treatment with GLP1RAs resulted in unaffected or reduced Cmax and delayed tmax of drugs with high solubility and permeability (warfarin, contraceptive pills, acetaminophen), drugs with high solubility and low permeability (angiotensin converting enzyme inhibitors), drugs with low solubility and high permeability (statins) and drugs with low solubility and permeability (digoxin)

Standard Berberine often struggles with poor bioavailability and occasional digestive discomfort