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Importantly for the availability of coverage across the workforce, the share of firms with 5,000 or more workers covering these medications for weight loss increased significantly over the last year (from 28% in 2024 to 43% in 2025)

The clinical significance of anti-exenatide antibody formation is unknown at this time

Other new treatments that have come on-stream or will do so in 2025, particular in the central nervous system/CNS category and neurological conditions are also expected to drive up costs in 2025

Well-studied, well-tolerated for most clients, and an excellent starting point for those new to GLP-1 therapy

In the second study, the authors reported a significant reduction of total testosterone and LH in only metformin group, while treatment with liraglutide led to a significant LH increase, without differences in FG score between the two groups [58]