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reported in a cohort study ( n = 16,827) that there was a higher risk of NAION in individuals prescribed semaglutide (HR 4.28) (89)
For type 2 diabetes management, lower to moderate doses may still deliver therapeutic benefit without pushing patients into higher risk of GI-related side effects
Other third-line options with lesser evidence include adjunctive bright light therapy, N-acetylcysteine, and eicosatetraenoic acid
Continuous therapy, even at lower maintenance doses, generally prevents the rebound that interruptions trigger
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