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Anal fissures are small tears or cuts in the mucosal lining, a thin and delicate lining, of the anus

These comorbidities are interlinked via shared immunopathogenic mechanisms, notably chronic low-grade inflammation driven by Th1/Th17 cytokines such as TNF, IL-6, and IL-17

Understanding provider scope, patient eligibility, and individual response factors helps optimize treatment safety and

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