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Medication works best alongside nutrition and lifestyle support

Weight Loss Effect of Glucagon-Like Peptide-1 Mimetics on Obese/Overweight Adults Without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Notably, caloric restriction (CR) and moderate weight loss (approximately 510%) improve insulin sensitivity despite the accompanying loss of muscle mass, and the observed reduction appears to result primarily from increased proteolysis rather than reduced protein synthesis

3 That would imply that GLP-1 works to moderate the movement of foods in order to maximize the absorption of nutrients, a process which also contributes to a reduction in appetite and a benefit to healthy weight management