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Originally used to treat type 2 diabetes , these drugs have also gained attention for their effectiveness in weight loss

47 In patients with overweight or obesity without diabetes, the Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1) trial showed that tirzepatide 15 mg weekly led to a mean body weight reduction of 20.9% after 72 weeks of treatment, compared with 3.1% with placebo

Kehrenberg and Bachmann)

Metformin reduces liver glucose output while semaglutide enhances pancreatic insulin releasethey work synergistically rather than against each other