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[1] [2] While there is no definitive evidence of this risk in humans, patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use these medications

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Glucagon-like peptide-1 receptor agonist semaglutide improves eating behavior and glycemic control in Japanese obese type 2 diabetic patients

[7] A boxed warning in the US prescribing information cautions that medullary thyroid cancers have been observed in rats treated with liraglutide, but it is "unknown whether liraglutide causes thyroid C-cell tumors, including medullary thyroid carcinoma, in humans, as relevance to humans of such tumors in rodents has not been determined." [7] Thyroid cancer [edit] At exposures eight times greater than those used in humans, liraglutide caused a statistically significant increase in thyroid tumors in rats