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Additionally, severe, persistent abdominal pain radiating to the back, especially if accompanied by vomiting, requires urgent medical attention as it may indicate pancreatitis, a rare but serious side effect of GLP-1 receptor agonists

In fact, many patients dont make it to the highest dose, even with expert care

If symptoms are particularly troublesome, your doctor may recommend: Slower dose escalation than standard protocols Temporary dose reduction Switching to a different GLP-1 agonist, as individual responses vary Short-term use of anti-diarrhoeal medications such as loperamide for acute episodes, though this should only be done under medical supervision and avoided if you have blood in your stool, fever, or suspected infection If you're also taking insulin or sulfonylureas, monitor your blood glucose more frequently during periods of reduced appetite or diarrhoea, as you may need dose adjustments to prevent hypoglycaemia