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Finally, the neurobiological heterogeneity across SUDs underscores the importance of substance-specific clinical trials tailored to distinct mechanisms and outcome measures

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GLP-1 medications including tirzepatide are not contraindicated in hypothyroidism, but require TSH and free T4 monitoring before and during treatment

Essential demographic data included age, sex, and ethnicity, as well as existing comorbidities and medication usage

Another study found that liraglutide alleviated thermal and mechanical allodynia through suppression of brain microglia NOD-like receptor protein 3 (NLRP3) inflammasome activation in diabetic rats [83]