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Description
Across clinical trials and real-world settings, weight loss remained modest, relapse rates after discontinuation were high, and treatment was often fragmented, lacking integration into interdisciplinary care models
As a result, GIP was designated as the first incretin (1, 12)
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Novo is defending with semaglutide, amylin combinations, and oral semaglutide
Additionally, GLP-1RAs may activate receptors in cardiac myocytes, leading to the secretion of atrial natriuretic peptide (ANP), which promotes natriuresis, vasodilation, and inhibition of the RAAS [90]
