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Additionally, lipid administration to the duodenum of healthy subjects induces greater GIP secretion than isocaloric glucose administration [51], suggesting an important role for GIP in the regulation of lipid metabolism

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This dominance is driven by the clinical success and regulatory approval of highly effective therapeutic agents targeting both central and peripheral mechanisms of obesity

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Moreover, GLP-1 antagonists were also found to enhance resting state functional connectivity between the hypothalamus and the left lateral OFC, and the left amygdala (Meyer-Gerspach et al., 2018)

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(2013) expanded this evidence base by systematically evaluating the effects of Ex4 on locomotor activity, NAc dopamine release, and reward-associated learning induced by both cocaine and amphetamine

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