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Additionally, lipid administration to the duodenum of healthy subjects induces greater GIP secretion than isocaloric glucose administration [51], suggesting an important role for GIP in the regulation of lipid metabolism

This dominance is driven by the clinical success and regulatory approval of highly effective therapeutic agents targeting both central and peripheral mechanisms of obesity
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Moreover, GLP-1 antagonists were also found to enhance resting state functional connectivity between the hypothalamus and the left lateral OFC, and the left amygdala (Meyer-Gerspach et al., 2018)

(2013) expanded this evidence base by systematically evaluating the effects of Ex4 on locomotor activity, NAc dopamine release, and reward-associated learning induced by both cocaine and amphetamine
