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Upper/Lower Gastrointestinal Symptoms Adverse event reporting databases, RCTs, and real-world data consistently show that GLP-1 RAs are commonly associated with GI symptoms such as nausea, vomiting, diarrhea, constipation, abdominal pain, and dyspeptic complaints

Perhaps more concerning is that 11 to 50% of total weight loss in GLP-1 RA users is attributed to loss of lean body mass, which may detrimentally include loss of skeletal muscle 26 , potentially negatively impacting metabolism, strength and long-term health

239 AstrupACarraroRFinerNHarperAKunesovaMLeanMEet al

Sometimes there's so much food left that doctors can't complete the procedure20.1% of endoscopies get canceled [3]

Use of GLP-1 receptor agonists and subsequent risk of alcohol-related events