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Likewise, as patients progress and require triple therapy, these medication classes comprise options in combination with a variety of other antihyperglycemic medication classes

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Tirzepatide is a dual-action medication that targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide), offering potentially stronger effects for certain users

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Risk of bias for the change in HbA 1c was assessed as low in all trials except for one that was at high risk of bias and one with some concerns (ESM Table 2)

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