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To be clear, studies suggest that GLP-1s generally lead to greater and faster weight loss results than relying solely on lifestyle changes like diet and exercise

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Reduced-Frequency GLP1 Therapy Maintains Weight, Body Composition, and Metabolic Syndrome Improvements: A Case Series

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This study demonstrated significant improvements in parameters such as HbA1c, body weight, and lipid profiles, along with a reduced need for rescue medications to control hyperglycemia (107), an effect that has been demonstrated again in other meta-analyses carried out subsequently (108)

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How Metformin Works Metformin mainly acts on the liver to lower the production of glucose, which helps bring down blood sugar levels

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it often improves as inflammation decreases and metabolic health improves

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