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The most important limitation with regard to nonsurgical treatment of GLP-1-based weight loss patients is the current lack of clinical data specific to these individuals

However, after exendin-4 stimulation, the receptor association with clathrin-positive regions increased, an effect that correlates with the known rapid GLP-1R internalisation triggered by exendin-4 (31), with this increase however significantly less pronounced for the GLP-1R V229A compared to WT (F/S = 0.16 0.006 and 0.10 0.004 for WT versus V229A, respectively), in agreement with the reduced internalisation propensity displayed by this mutant receptor (Figure 2H)
However, their effectiveness and risks have not yet been systematically evaluated in a comprehensive set of possible health outcomes

Research shows that GLP-1 receptors are present in reproductive tissues, suggesting direct effects on sexual organs