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However, it should be considered that these adverse effects are considered mild to moderate, and there is no significant probability of serious adverse effects [155] or an adverse reaction to SMG when compared to placebo [157]

We used n = 79 per group to allow for strength of statistical outcomes and each in vivo study was replicated three times

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More serious risks include pancreatitis, gallbladder disease, acute kidney injury with dehydration, suicidal ideation, and potential thyroid C-cell tumors (observed in rodent studies, though human relevance remains uncertain)