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OSA is a highly prevalent condition, strongly associated with obesity and linked to an increased risk of cardiovascular disease

Notably, GLP-1RAs benefit pain management through their neuroprotective and metabolic regulatory properties, such as inhibiting inflammation responses and oxidative stress, promoting -endorphin release and modulating several other crucial biological pathways

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Retatrutide reported up to 28.7% average weight loss and pain reduction of up to 75.8% on the WOMAC scale in adults with obesity and knee osteoarthritis [9]

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