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Description
Earlier formulations required frequent dosing, but newer agents like Dulaglutide and Semaglutide provide once-a-week dosing, and regulators approved an oral Semaglutide formulation (18)(21)(27)
This is particularly noteworthy because two competing oral small-molecule GLP-1 programs from Pfizer, lotiglipron (discontinued in 2023) and danuglipron (discontinued in April 2025), were terminated due to liver toxicity concerns
As the popularity of these medications grows, so does the need for better awareness and clearer communication of possible complications
Semaglutide comes in two forms: oral tablets ( Rybelsus , Wegovy pill ) and injections ( Ozempic , Wegovy )
Weight loss varies by state
