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Description
While the body does produce natural GLP-1, this endogenous hormone is rapidly broken down by the enzyme dipeptidyl peptidase-4 (DPP-4) within minutes of secretion, making it unsuitable as a therapeutic agent without pharmaceutical modification

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Pedersen SD, Giorgino F, Umpierrez G, Thieu VT, Rodrguez A, Nicolay C, et al

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